5-Sulfonyl-benzimidazoles as selective CB2 agonists – Part 2 was written by Gijsen, Harrie J. M.;De Cleyn, Michel A. J.;Surkyn, Michel;Van Lommen, Guy R. E.;Verbist, Bie M. P.;Nijsen, Marjoleen J. M. A.;Meert, Theo;Van Wauwe, Jean;Aerssens, Jeroen. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.HPLC of Formula: 144222-22-0 This article mentions the following:
In a previous communication, the SAR of a series of potent and selective 5-sulfonylbenzimidazole CB2-receptor agonists was described. The lack of in vivo activity of compounds from this series was attributed to their poor solubility and metabolic stability. In this Letter, we report on further optimization of this series, leading to the relatively polar and peripherically acting CB2 agonists I and II. Although both compounds were not active in acute pain models, the less selective compound I displayed good, sustained activity in a chronic model of neuropathic pain without the tolerance observed with morphine. In addition, both I and II delayed the onset of clin. symptoms in an exptl. model for multiple sclerosis. In the experiment, the researchers used many compounds, for example, 1-Boc-4-(Aminomethyl)piperidine (cas: 144222-22-0HPLC of Formula: 144222-22-0).
1-Boc-4-(Aminomethyl)piperidine (cas: 144222-22-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.HPLC of Formula: 144222-22-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem