The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effects of groups on the reaction rate. Reaction of α,β-dibromides with sodium iodide》. Authors are Davis, Tenney L.; Heggie, Robert.The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).Recommanded Product: 600-05-5. Through the article, more information about this compound (cas:600-05-5) is conveyed.
The rates of reaction at several temperatures of NaI in alc. with the dibromides of certain unsaturated aliphatic compounds and in Me2CO with the dibromides of substituted chalcones were measured. Good 2nd-order constants were obtained in all cases except those involving MeCHBrCH2Br and PrCHBrCH2Br. Constants of the 1st order were also unsatisfactory for these cases. The reaction of α,β-dibromopropionic acid with NaI was much faster in Me2CO than in alc. In the aliphatic series compounds containing electron-attracting groups reacted much faster than those containing groups which tend to supply electrons. Substituted chalcone dibromides reacted more rapidly than simple chalcone dibromide. The energy of activation, E, was calculated for several reactions and the probability factors were calculated from the equation, K = PZe-E/RT. The Me, Pr and CH2OH groups increased E; the CO2Et and CO2H groups decreased E; 2 CO2H groups had more effect than one; the effect of one CO2H was greater than the opposing effect of a Me group. A CO2H group reduced P; a 2nd CO2H group increased P, but not to the value possessed by the compound containing H instead of CO2H.
Different reactions of this compound(2,3-Dibromopropionic acid)Recommanded Product: 600-05-5 require different conditions, so the reaction conditions are very important.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem