Related Products of 144222-22-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Boc-4-(Aminomethyl)piperidine, is researched, Molecular C11H22N2O2, CAS is 144222-22-0, about Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors. Author is Plewe, Michael B.; Sokolova, Nadezda V.; Gantla, Vidyasagar Reddy; Brown, Eric R.; Naik, Shibani; Fetsko, Alexandra; Lorimer, Donald D.; Dranow, David M.; Smutney, Hayden; Bullen, Jameson; Sidhu, Rana; Master, Arshil; Wang, Junru; Kallel, E. Adam; Zhang, Lihong; Kalveram, Birte; Freiberg, Alexander N.; Henkel, Greg; McCormack, Ken.
We identified and explored the structure-activity-relationship (SAR) of an adamantane carboxamide chem. series of Ebola virus (EBOV) inhibitors. Selected analogs exhibited half-maximal inhibitory concentrations (EC50 values) of ~10-15 nM in vesicular stomatitis virus (VSV) pseudotyped EBOV (pEBOV) infectivity assays, low hundred nanomolar EC50 activity against wild type EBOV, aqueous solubility >20 mg/mL, and attractive metabolic stability in human and nonhuman liver microsomes. X-ray cocrystallog. characterizations of a lead compound with the EBOV glycoprotein (GP) established the EBOV GP as a target for direct compound inhibitory activity and further provided relevant structural models that may assist in identifying optimized therapeutic candidates.
《Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Boc-4-(Aminomethyl)piperidine)Related Products of 144222-22-0.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem