Synthesis and bioactivities of novel 4,5,6,7-Tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-α (TNF-α) production was written by Fujita, Masakazu;Seki, Taketsugu;Inada, Haruaki;Ikeda, Naoko. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Electric Literature of C7H13NO This article mentions the following:
Novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives were synthesized and evaluated for their abilities to inhibit lipopolysaccharide (LPS)-stimulated production of TNF-α in rat whole blood. Several of these compounds exhibited potent inhibitory activity. In the experiment, the researchers used many compounds, for example, 1-Ethylpiperidin-4-one (cas: 3612-18-8Electric Literature of C7H13NO).
1-Ethylpiperidin-4-one (cas: 3612-18-8) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Electric Literature of C7H13NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem