Fries, David S.’s team published research in Journal of Medicinal Chemistry in 20 | CAS: 13444-24-1

Journal of Medicinal Chemistry published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, SDS of cas: 13444-24-1.

Fries, David S. published the artcileSynthesis and preliminary pharmacological activity of aminoalkoxy isosteres of glycolate ester anticholinergics, SDS of cas: 13444-24-1, the publication is Journal of Medicinal Chemistry (1977), 20(10), 1250-4, database is CAplus and MEDLINE.

Five 2-[(dialkylamino)alkoxy]-1,1-diphenylethanols and 5 2-(N-heterocycleoxy)-1,1-diphenylethanols were prepared by the reaction of 2,2-diphenyloxirane [882-59-7] with the alkoxide form of the appropriate amino alc. Most of the compounds had moderate anticholinergic activity when tested on the isolated rat jejunum or for inhibition of perphenazine-induced catatonia in rats. The most active compounds were I [63624-24-8], II [63624-25-9], and III [63624-26-0]. Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, SDS of cas: 13444-24-1.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem