Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: A proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes was written by Finke, P. E.;Meurer, L. C.;Oates, B.;Shah, S. K.;Loebach, J. L.;Mills, S. G.;MacCoss, M.;Castonguay, L.;Malkowitz, L.;Springer, M. S.;Gould, S. L.;DeMartino, J. A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Recommanded Product: 4-(2-Methoxyphenyl)piperidine This article mentions the following:
Structure-activity relationship studies directed toward the optimization of (2S)-2-(3-chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[4-(substituted)piperidin-1-yl]butanes as CCR5 antagonists resulted in the synthesis of the spiro-indanone derivative I (IC50=5 nM). These and previous results are summarized in a proposed pharmacophore model for this class of CCR5 antagonist. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Recommanded Product: 4-(2-Methoxyphenyl)piperidine).
4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 4-(2-Methoxyphenyl)piperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem