Application of 143900-43-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 143900-43-0, Name is (R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, molecular formula is C10H19NO3. In a Article，once mentioned of 143900-43-0
Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of 5-(pyrimidin-2-ylamino)picolinonitrile derivatives as CHK1 inhibitors were discovered by further rational optimization. One promising molecule, (R)-17, whose potency was one of the best, had an IC50 of 0.4 nM with remarkable selectivity (>4300-fold CHK1 vs. CHK2). Compound (R)-17 effectively inhibited the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 muM) and displayed low affinity for hERG (IC50 > 40 muM). Moreover, (R)-17 significantly suppressed the tumor growth in Z-138 cell inoculated xenograft model (20 mg/kg I.V., TGI = 90.29%) as a single agent with body weight unaffected. Taken together, our data demonstrated compound (R)-17 could be a promising drug candidate for the treatment of hematologic malignancies.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application of 143900-43-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 143900-43-0, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H14636N – PubChem