Final Thoughts on Chemistry for N,N-Dimethylpiperidin-4-amine

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1-[(3- or 4-Benzoylphenyl)-lower-alkyl]-[(CH2)n –N=B]-substituted-piperidines, useful as anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory agents, are prepared by alkylation of an appropriate substituted piperidine with a (3- or 4-benzoylphenyl)-lower-alkyl halide or tosylate; by reaction of a 1-[2-(3- or 4-lithiophenyl)-lower-alkyl]-[(CH2)n –N=B]-substituted-piperidine with benzonitrile and hydrolysis of the resulting benzimidoyl compound; or by reduction of a 1-[alpha-(3- or 4-benzoylphenyl)-lower-alkanoyl]-[(CH2)n –N=B]-substituted-piperidine. The analogous carbinols are prepared by reduction, with an alkali metal borohydride, of the ketone.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H4007N – PubChem