Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 10310-21-1, Name is 2-Amino-6-chloropurine, molecular formula is C5H4ClN5, belongs to piperidines compound. In a document, author is Vargas-Caporali, Jorge, introduce the new discover, Formula: C5H4ClN5.
Synthesis of Diastereomeric Pyrrolidine Sulfamides via Anchimerically Assisted Nucleophilic Substitution Reactions
The Mitsunobu reaction was employed in a key step during the development of a convenient synthetic route for the enantioselective preparation of pyrrolidine-sulfamide ligands from (R)-or (S)- [(S)-1-benzylpyrrolidin-2-yl](phenyl) methanol, and employing tert-butyl pyrrolidin-1-yl-sulfonylcarbamate as a non-conventional nucleophilic source. Although it is well documented that the exposure of this type of diastereomeric amino alcohols to the above-mentioned nucleophile usually leads to the formation of piperidines via ring expansion, either through classical nucleophilic substitution or the Mitsunobu version, only the pyrrolidine derivatives were generated with retention of configuration on the exocyclic stereocenter, owing to the neighboring group participation (internal backside nucleophilic substitution, S(N)ib). Final removal of the N-Boc protecting group from the sulfamide fragment afforded chiral compounds with significant potential as chiral ligands in asymmetric catalysis.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 10310-21-1. Formula: C5H4ClN5.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem