98303-20-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 98303-20-9, Name is 1-(tert-Butoxycarbonyl)piperidine-2-carboxylic acid, molecular formula is C11H19NO4. In a Article, authors is Nikulnikov, Mikhail£¬once mentioned of 98303-20-9
A convenient preparation of diastereomerically pure, diversely substituted piperazine-2,5-diones from n-protected -amino acids
The products of the Ugi reaction of various N-tert-butoxycarbonyl-protected -amino acids, aldehydes, amines and tert-butyl isocyanide, after tert-butoxycarbonyl deprotection, undergo efficient microwave-assisted cyclization in acetic acid to give diastereomerically pure, racemic piperazine-2,5-diones. The formation of a single diastereomer is rationalized via an enolization equilibration process in acetic acid at high temperature which enriches the product mixture in the more stable diastereomer. The relative stereochemistry of the products are confirmed by NOESY experiments and are consistent with molecular mechanics calculations. Georg Thieme Verlag Stuttgart New York.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 98303-20-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 98303-20-9, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18474N – PubChem