In an article, author is Forcellini, Elsa, once mentioned the application of 22990-77-8, Safety of 2-Piperidylmethylamine, Name is 2-Piperidylmethylamine, molecular formula is C6H14N2, molecular weight is 114.19, MDL number is MFCD00129011, category is piperidines. Now introduce a scientific discovery about this category.
Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1
The ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) was recently shown to promote mineralization of the aortic valve, hence, its inhibition represents a significant target. A quinazoline-4. piperidine sulfamide compound (QPS1) has been described as a specific and non-competitive inhibitor of NPP1. We report herein the synthesis and in vitro inhibition studies of novel quinazoline-4-piperidinc sulfamide analogues using QPS1 as the lead compound. Of the 26 derivatives prepared, four compound were found to have K-i < 105 nM against human NPP1. (C) 2018 Elsevier Masson SAS. All rights reserved If you are interested in 22990-77-8, you can contact me at any time and look forward to more communication. Safety of 2-Piperidylmethylamine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem