Favretto, Donata; Stocchero, Giulia; Nalesso, Alessandro; Vogliardi, Susanna; Boscolo-Berto, Rafael; Montisci, Massimo; Ferrara, Santo D. published an article in 2013, the title of the article was Monitoring Haloperidol Exposure in Body Fluids and Hair of Children by Liquid Chromatography-High-Resolution Mass Spectrometry.Related Products of 39512-49-7 And the article contains the following content:
Background: Haloperidol, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone (HP), one of the most widely used antipsychotics in the treatment of schizophrenia, mania, and other psychiatric disorders, is frequently encountered in cases of unintentional pediatric intoxication because the ingestion of a small amount can cause significant toxic effects in children. For monitoring HP in suspected ingestions, a liquid chromatog.-high-resolution mass spectrometry method has been developed and validated in urine, blood, and hair samples. Methods: The analyte was extracted from 1 mL blood or urine by liquid/liquid extraction and from 5 mg of hair by micropulverized extraction; gradient elution on an Atlantis T3 column was realized using HP-d4 as an internal standard Pos. ion electrospray ionization and high-resolution mass spectrometry determination were performed in an Orbitrap mass spectrometer. Results: The method exhibited a r > 0.999 in the studied ranges (0.1-50 ng/mL in urine and blood and 0.1-50 ng/mg in hair) and a limit of quantification of 0.1 ng/mL for urine and blood and 0.1 ng/mg for hair; intra-assay and interassay relative SDs were always more than 18%. The method was applied to determine haloperidol in 3 children who were admitted to emergency departments. HP concentrations ranged from 2 to 21 ng/mL in urine, from not detected to 4.9 ng/mL in blood, and from 0.37 to 0.73 ng/mg in hair samples. Conclusions: The utilization of high-resolution/high-accuracy mass spectrometry in full scan mode allowed the identification of HP metabolites in urine and blood, thus unequivocally documenting the exposure to the drug. HP metabolites were structurally characterized by high-resolution multiple mass spectrometry. For the first time, a HP metabolite was detected in hair. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Related Products of 39512-49-7
The Article related to liquid chromatog high resolution mass spectrometry haloperidol metabolite hair, body fluid child intoxication, Pharmacology: Drug Metabolism and other aspects.Related Products of 39512-49-7
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem