A Noncoordinating Acid-Base Catalyst for the Mild and Nonreversible tert-Butylation of Alcohols and Phenols was written by Fandrick, Keith R.;Patel, Nitinchandra D.;Radomkit, Suttipol;Chatterjee, Arindom;Braith, Stefan;Fandrick, Daniel R.;Busacca, Carl A.;Senanayake, Chris H.. And the article was included in Journal of Organic Chemistry in 2021.Electric Literature of C11H21NO3 This article mentions the following:
A mild and nonreversible tert-butylation of alcs. and phenols can be achieved in high yields using the noncoordinating acid-base catalyst [bis(trifluoromethane)sulfonimide and 2,6-lutidine] with a tert-butylation reagent, tert-Bu 2,2,2-trichloroacetimidate. This method allows the use of substrates containing acid sensitive groups such as ketal, Boc, and boronate esters. In the experiment, the researchers used many compounds, for example, 1-Boc-4-Hydroxy-4-methylpiperidine (cas: 406235-30-1Electric Literature of C11H21NO3).
1-Boc-4-Hydroxy-4-methylpiperidine (cas: 406235-30-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 浼?glucosidase inhibitors. The former are analogs of DNJ with an improved 浼?glucosidase inhibitory profile than that of DNJ. Boisson et al.Electric Literature of C11H21NO3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem