《Novel pleuromutilin derivatives with substituted 6-methylpyrimidine: Design, synthesis and antibacterial evaluation》 was written by Fan, Yuan; Liu, Yu; Wang, Hao; Shi, Tao; Cheng, Feng; Hao, Baocheng; Yi, Yunpeng; Shang, Ruofeng. SDS of cas: 622-26-4 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:
A series of novel pleuromutilin derivatives with substituted 6-methylpyrimidine moieties was designed, synthesized, and evaluated for their antibacterial activities. Most of the tested compounds exhibited potent antibacterial activities against Staphylococcus aureus ATCC 25923 (S. aureus-25923), methicillin-resistant Staphylococcus epidermidis ATCC 51625 (MRSE-51625), methicillin-resistant Staphylococcus aureus BNCC 337371 (MRSA-337371), Streptococcus dysgalactiae (S. dysgalactiae) and Streptococcus agalactiae (S. agalactiae). Compounds I (NR1R2 = pyrrolidino, morpholino) were the most active and displayed bacteriostatic activities against MRSA. In vivo mouse systemic infection experiment showed that I (NR1R2 = pyrrolidino) significantly improved the survival rate of mice (ED50 = 18.02 mg/kg), reduced the bacterial load and alleviated the pathol. changes in the lungs of the affected mice. In the part of experimental materials, we found many familiar compounds, such as 2-(Piperidin-4-yl)ethanol(cas: 622-26-4SDS of cas: 622-26-4)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKSDS of cas: 622-26-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem