Chemistry is an experimental science, Recommanded Product: 41994-45-0, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 41994-45-0, Name is Methyl 2-piperidinecarboxylate
Alkoxycarbonylpiperidines as N-nucleophiles in the palladium-catalyzed aminocarbonylation
Piperidines possessing ester functionality, such as 2-(methoxycarbonyl) piperidine (methyl pipecolinate), 3-(ethoxycarbonyl)piperidine (ethyl nipecotate), and 4-(ethoxycarbonyl)piperidine (ethyl isonipecotate), were used as N-nucleophiles in palladium-catalyzed aminocarbonylation of iodobenzene and iodoalkenes such as 1-iodocyclohexene and 17-iodoandrost-16-ene. While the aminocarbonylation of both iodoalkenes, carried out under mild reaction conditions, resulted in the exclusive formation of the carboxamide, the same reaction of iodobenzene brought about the mixture of the corresponding carboxamide and 2-ketocarboxamide. The chemoselectivity toward the latter compounds, formed via double carbonyl insertion, was substantially increased by using high carbon monoxide pressure (up to 40 bar). Carboxamides derived from iodoalkenes and ketocarboxamides derived from iodoarene have been obtained in moderate to high yields. Graphical abstract: [Figure not available: see fulltext.]
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 41994-45-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 41994-45-0, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H7088N – PubChem