Electric Literature of 142752-12-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 142752-12-3, Name is 1-(4-Aminophenyl)piperidin-4-ol, molecular formula is C11H16N2O. In a Article£¬once mentioned of 142752-12-3
Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes
Activation of various interacting stress kinases, particularly the c-Jun N-terminal kinases (JNK), and a concomitant phosphorylation of insulin receptor substrate 1 (IRS-1) at serine 307 play a central role both in insulin resistance and in beta-cell dysfunction. IRS-1 phosphorylation is stimulated by elevated free fatty acid levels through different pathways in obesity. A series of novel pyrido[2,3-d]pyrimidin-7-one derivatives were synthesized as potential antidiabetic agents, preventing IRS-1 phosphorylation at serine 307 in a cellular model of lipotoxicity and type 2 diabetes.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 142752-12-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 142752-12-3, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H12860N – PubChem