Chemistry is an experimental science, COA of Formula: C8H16ClNO, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 3970-79-4, Name is 1-Oxa-8-azaspiro[4.5]decane hydrochloride
Decaprenylphosphoryl-beta-d-ribose 2?-epimerase (DprE1) is an essential enzyme in Mycobacterium tuberculosis and has recently been studied as a potential drug target, with inhibitors progressing to clinical studies. Here we describe the identification of a novel series of morpholino-pyrimidine DprE1 inhibitors. These were derived from a phenotypic high-throughput screening (HTS) hit with suboptimal physicochemical properties. Optimization strategies included scaffold-hopping, synthesis, and evaluation of fragments of the lead compounds and property-focused optimization. The resulting optimized compounds had much improved physicochemical properties and maintained enzyme and cellular potency. These molecules demonstrated potent efficacy in an in vivo tuberculosis murine infection model.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C8H16ClNO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3970-79-4, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H10769N – PubChem