Extracurricular laboratory: Synthetic route of 177-11-7

Computed Properties of C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX or concate me.

Computed Properties of C7H13NO2. Recently I am researching about BINAPHTHOL DERIVATIVES; C(SP(3))-H BONDS; ARENES; HYDROXYLATION; C(SP(2))-H; FUNCTIONALIZATION; MECHANISM; MILD, Saw an article supported by the Shanghai Institute of Materia Medica, Chinese Academy of SciencesChinese Academy of Sciences; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772211]; Youth Innovation Promotion Association CAS [2014229, 2018293]; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0120163006]; Science and Technology Commission of Shanghai MunicipalityScience & Technology Commission of Shanghai Municipality (STCSM) [17JC1405000]; Program of Shanghai Academic Research Leader [19XD1424600]; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2018ZX09711002-006]; State Key Laboratory of Natural and Biomimetic Drugs. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

Computed Properties of C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX or concate me.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem