Extracurricular laboratory: Synthetic route of 175136-62-6

Compounds in my other articles are similar to this one(Tris(3,5-bis(trifluoromethyl)phenyl)phosphine)Name: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yao, Huifang; Liu, Yong; Tyagarajan, Sriram; Streckfuss, Eric; Reibarkh, Mikhail; Chen, Kuanchang; Zamora, Ismael; Fontaine, Fabien; Goracci, Laura; Helmy, Roy; Bateman, Kevin P.; Krska, Shane W. researched the compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine( cas:175136-62-6 ).Name: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine.They published the article 《Enabling Efficient Late-Stage Functionalization of Drug-Like Molecules with LC-MS and Reaction-Driven Data Processing》 about this compound( cas:175136-62-6 ) in European Journal of Organic Chemistry. Keywords: late stage drug functionalization LCMS automated reaction data processing. We’ll tell you more about this compound (cas:175136-62-6).

Late-stage functionalization (LSF) through C-H functionalization of drug leads is a powerful synthetic strategy for drug discovery. A key challenge in LSF is that multiple regioisomeric products are often generated, which requires slow and laborious product isolation and structure confirmation steps. To address this, an anal. approach using LC-HR-MS/MS coupled with automated chem. aware data processing was developed. Using this method to analyze reaction screening arrays based on three common C-H functionalization chemistries with a set of marketed drugs, the relative amount and localization of chem. modification could be determined for each regioisomeric product generated in the screening. This approach allows one to construct a workflow in which the various regioisomeric products of a given transformation are triaged according to their site of modification, allowing downstream isolation and structure elucidation efforts to focus on those analogs of highest interest, leading to an overall increase in productivity of the LSF strategy.

Compounds in my other articles are similar to this one(Tris(3,5-bis(trifluoromethyl)phenyl)phosphine)Name: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem