The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine( cas:175136-62-6 ) is researched.SDS of cas: 175136-62-6.Zhou, Xuan; Dong, Guangbin published the article 《(4+1) vs. (4+2): Catalytic Intramolecular Coupling between Cyclobutanones and Trisubstituted Allenes via C-C Activation》 about this compound( cas:175136-62-6 ) in Journal of the American Chemical Society. Keywords: coupling intramol cyclobutanone allene rhodium catalyst; enantioselective intramol coupling cyclobutanone allene rhodium catalyst; bicyclic skeleton preparation. Let’s learn more about this compound (cas:175136-62-6).
Herein, we describe a rhodium-catalyzed [4+1]-cyclization between cyclobutanones and allenes, which provides a distinct [4.2.1]-bicyclic skeleton containing two quaternary carbon centers. The reaction involves C-C activation of cyclobutanones and employs allenes as a one-carbon unit. A variety of functional groups can be tolerated, and a diverse range of polycyclic scaffolds can be accessed. Excellent enantioselectivity can be obtained, which is enabled by a TADDOL-derived phosphoramidite ligand. The bridged bicyclic products can be further functionalized or derivatized though simple transformations.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem