Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 120-73-0, Name is Purine, SMILES is C12=NC=NC1=CNC=N2, belongs to piperidines compound. In a document, author is Sharma, Neha, introduce the new discover, Formula: C5H4N4.
Multistage antiplasmodial activity of hydroxyethylamine compounds,in vitroandin vivoevaluations
Malaria, a global threat to the human population, remains a challenge partly due to the fast-growing drug-resistant strains ofPlasmodiumspecies. New therapeutics acting against the pathogenic asexual and sexual stages, including liver-stage malarial infection, have now attained more attention in achieving malaria eradication efforts. In this paper, two previously identified potent antiplasmodial hydroxyethylamine (HEA) compounds were investigated for their activity against the malaria parasite’s multiple life stages. The compounds exhibited notable activity against the artemisinin-resistant strain ofP. falciparumblood-stage culture with 50% inhibitory concentrations (IC50) in the low micromolar range. The compounds’ cytotoxicity on HEK293, HepG2 and Huh-7 cells exhibited selective killing activity with IC(50)values > 170 mu M. Thein vivoefficacy was studied in mice infected withP. bergheiNK65, which showed a significant reduction in the blood parasite load. Notably, the compounds were active against liver-stage infection, mainly compound1with an IC(50)value of 1.89 mu M. Mice infected withP. bergheisporozoites treated with compound1at 50 mg kg(-1)dose had markedly reduced liver stage infection. Moreover, both compounds prevented ookinete maturation and affected the developmental progression of gametocytes. Further, systematicin silicostudies suggested both the compounds have a high affinity towards plasmepsin II with favorable pharmacological properties. Overall, the findings demonstrated that HEA and piperidine possessing compounds have immense potential in treating malarial infection by acting as multistage inhibitors.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 120-73-0 is helpful to your research. Formula: C5H4N4.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem