Reference of 29976-53-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 29976-53-2, Name is N-Carbethoxy-4-piperidone, molecular formula is C8H13NO3. In a Article,once mentioned of 29976-53-2
Analysis of the structural requirements of compound 1 (SR48968), a potent NK2 receptor antagonist, revealed that the 4-phenyl group of the piperidine is essential for binding with the NK2 receptor and occupies an equatorial position. Energy calculation of a variety of substituted 4-phenyl piperidines revealed that spiro[isobenzofuran-1(3H), 4′-piperidine] possesses a conformationally restricted equatorial phenyl group. Our compound 12 (YM- 35375) possessing this spiro-substituted piperidine bound to the NK2 receptor with an IC50 value of 84nM and to the NK1 receptor with an IC50 value of 710nM. It showed more potent inhibitory activity (ID50 41mug/kg (i.v.)) against [beta-Ala8]-NKA(4-10)-induced bronchoconstriction in guinea pigs than (±)-SR48968 (ID50 68mug/kg (i.v.)). YM-35375 may be a new lead compound for novel NK2 receptor antagonists or NK1-NK2 dual antagonists.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Reference of 29976-53-2, you can also check out more blogs about29976-53-2
Reference:
Piperidine – Wikipedia,
Piperidine | C5H10127N – PubChem