So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lee, Sumin; Rovis, Tomislav researched the compound: 1-Boc-4-(Aminomethyl)piperidine( cas:144222-22-0 ).Name: 1-Boc-4-(Aminomethyl)piperidine.They published the article 《Rh(III)-Catalyzed Three-Component Syn-Carboamination of Alkenes Using Arylboronic Acids and Dioxazolones》 about this compound( cas:144222-22-0 ) in ACS Catalysis. Keywords: amide preparation regioselective; alkene arylboronic acid dioxazolone three component carboamination rhodium catalyst; Carboamination; Rh(III) catalysis; alkene difunctionalization; directing group-free; α-amino acid synthesis. We’ll tell you more about this compound (cas:144222-22-0).
A Rh(III)-catalyzed three-component carboamination of alkenes, e.g., 1,4-dihydro-1,4-epoxynaphthalene from readily available aryl boronic acids R1B(OH)2 (R1 = C6H5, 1-naphthyl, 2H-1,3-benzodioxol-5-yl, etc.) as a carbon source and dioxazolones I (R2 = CH3, cyclopropyl, 2-cyclohexylethyl, etc.) as nitrogen electrophiles is described. This protocol provides facile access to valuable amine products including α-amino acid derivatives, e.g., II in good yield and regioselectivity without the need for a directing functionality. A series of experiments suggest a mechanism in which the Rh(III) catalyst undergoes transmetalation with the aryl boronic acid, followed by turnover limiting alkene migratory insertion into the Rh(III)-aryl bond. Subsequently, fast Rh-nitrene formation provides the syn-carboamination product selectively after reductive elimination and proto-demetalation. Importantly, the protocol provides three-component coupling products in preference to a variety of two-component undesired byproducts.
After consulting a lot of data, we found that this compound(144222-22-0)Name: 1-Boc-4-(Aminomethyl)piperidine can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem