Related Products of 142643-29-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 142643-29-6, Name is 3-(Boc-aminomethyl)piperidine, molecular formula is C11H22N2O2. In a Article£¬once mentioned of 142643-29-6
Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design
A HTS campaign identified compound 1, an excellent hit-like molecule to initiate medicinal chemistry efforts to optimize a dual ROCK1 and ROCK2 inhibitor. Substitution (2-Cl, 2-NH2, 2-F, 3-F) of the pyridine hinge binding motif or replacement with pyrimidine afforded compounds with a clean CYP inhibition profile. Cocrystal structures of an early lead compound were obtained in PKA, ROCK1, and ROCK2. This provided critical structural information for medicinal chemistry to drive compound design. The structural data indicated the preferred configuration at the central benzylic carbon would be (R), and application of this information to compound design resulted in compound 16. This compound was shown to be a potent and selective dual ROCK inhibitor in both enzyme and cell assays and efficacious in the retinal nerve fiber layer model after oral dosing. This tool compound has been made available through the AbbVie Compound Toolbox. Finally, the cocrystal structures also identified that aspartic acid residues 176 and 218 in ROCK2, which are glutamic acids in PKA, could be targeted as residues to drive both potency and kinome selectivity. Introduction of a piperidin-3-ylmethanamine group to the compound series resulted in compound 58, a potent and selective dual ROCK inhibitor with excellent predicted drug-like properties.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 142643-29-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 142643-29-6, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H16861N – PubChem