Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 108-26-9, Name is 3-Methyl-1H-pyrazol-5(4H)-one, molecular formula is , belongs to piperidines compound. In a document, author is Yamazaki, Shoko, Name: 3-Methyl-1H-pyrazol-5(4H)-one.
Synthesis of Piperidines via Intramolecular Hydride Transfer from alpha-Amino sp(3) Carbon Atoms to Ethenetricarboxylate-Derived Fragments and Further Cyclization
The cyclization of amides derived from ethenetricarboxylic acid bearing tert-amino groups has been examined. The amides were efficiently converted to piperidine derivatives (2-piperidones) upon heating in a polar solvent (e.g., DMSO or DMF) via intramolecular hydride transfer and subsequent ring closure. The reaction was less efficient in the presence of a Lewis acid. The reactivity varies depending on the alkyl substituents of tert-amino groups, probably due to steric effects. The hydride transfer/cyclization mechanism was investigated by DFT calculations. The reaction of the carboxylic acid and relatively bulky diamines such as diisopropyl-substituted diamine in the presence of amide condensation reagents at 60 degrees C gave the piperidine derivatives in a one-pot reaction. The reaction of the diisopropylamine substituted piperidine product with primary amines gave secondary amine-substituted piperidines.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 108-26-9, in my other articles. Name: 3-Methyl-1H-pyrazol-5(4H)-one.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem