Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Recommanded Product: 4-Piperidinol.
Elbadawi, Mostafa M.;Eldehna, Wagdy M.;Wang, Wenjie;Agama, Keli K.;Pommier, Yves;Abe, Manabu research published 《 Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity》, the research content is summarized as follows. Two novel series of 4-alkoxy-2-arylquinolines I (n = 1, 2; R = pyrrolidino, 4-hydroxypiperidino, piperidino, morpholino; X = Cl, CF3) were designed and synthesized based on SARs of the reported TOP1 inhibitors and structural features required for stabilization of TOP1-DNA cleavage complexes (TOP1ccs). The in vitro anticancer activity of these two series of compounds was evaluated at one dose level using NCI-60 cancer cell lines panel. Compounds with p-substituted Ph at C2 and Pr linker at C4, were the most potent and were selected for assay at five doses level in which they exhibited potent anticancer activity at sub-micromolar level against diverse cancer cell lines. Compound I (Ar = 4-F3CC6H4, 2-furyl, 2-thienyl, etc.; n = 2; R = pyrrolidino) was the most potent with full panel GI50 MG-MID 1.26μM and the most sensitive cancers were colon cancer, leukemia and melanoma. Melanoma (LOX IMVI) was the most sensitive cell line to all tested compounds displaying GI50 and LC50 at sub-micromolar concentration against almost of the tested compounds Few compounds were assayed using TOP1-mediated DNA cleavage assay to evaluate their ability to stabilize TOP1ccs resulting in cancer cell death. The morpholino analogs I (n = 2; R = morpholino; X = Cl, CF3) exhibited moderate TOP1 inhibitory activity compared to 1μM camptothecin suggesting their use as lead compounds that can be optimized for the development of more potent anticancer agents with potential TOP1 inhibitory activity.
Recommanded Product: 4-Piperidinol, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem