Ethynyl epoxides as synthons for 1,3-diketones and furans was written by Eichinger, Karl;Berbalk, Hans;Machat, Eduard;Wimmer, Johann. And the article was included in Journal of Chemical Research, Synopses in 1983.Safety of 1-Tosylpiperidin-4-one This article mentions the following:
Substituent effects were examined in the reaction of ethynyl epoxides I [X = CH2, CHMe, CHPh; R = Ph; X = CPh2, R = Me, Ph, 3,4-(MeO)2C6H3, 4-O2NC6H4] with HCO2H to give 1,3-diketones II and of I [X = CH2, CHMe, CHPh, SO2, NSO2C6H3Me-p, NCO2Et, CPh2, R = Ph; X = CPh2, R = Ph, 4-MeOC6H4, 3,4-(MeO)2C6H3, 4-O2NC6H4, 2,4-(O2N)2C6H3, Me] to give the corresponding furans III. The yields of furans were not markedly dependent on the nature of the substituents, whereas significant yields of 1,3-diketones were obtained only when R is moderately electron-withdrawing or -releasing. E.g., refluxing I (X = Ph2, R = Ph) (IV) with 95% aqueous HCO2H for 30 min gave 76% III (X = CPh2, R = Ph), whereas similar treatment of I [X = CPh2, R = 3,4-(MeO)2C6H3] gave only 6% III [X = CPh2, R = 3,4-(MeO)2C6H3]. Treatment of IV with HgSO4 in refluxing Me2CO-aqueous H2SO4 gave 79% II (X = CPh2, R = Ph). In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Safety of 1-Tosylpiperidin-4-one).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Safety of 1-Tosylpiperidin-4-one
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem