Recently I am researching about BIOLOGICAL EVALUATION; MMPL3; INHIBITION, Saw an article supported by the Ministry of Education (MoE) Academic Research FundMinistry of Education, Singapore [R148000234114, R148000286114]; Ministry of Health National Medical Research Council (Singapore)Ministry of Health-SingaporeNational Medical Research Council, Singapore [NMRC/TCR/011-NUHS/2014]; National Institute of Allergy and Infectious Diseases of the National Institutes of Health (USA)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI132374]; MoE SingaporeMinistry of Education, Singapore. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. HPLC of Formula: C7H13NO2
Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility. Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (33, MIC90Mtb , 0.13 mu M, MBC99.9Mtb, 0.63 mu M), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent. It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.
HPLC of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL or concate me.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem