914988-10-6, tert-Butyl 3-cyano-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred suspension of 51 (2-isobutoxy-6-methylphenyl)hydrazine hydrochloride (8.0 g, 39.9 mmol) in 42 EtOH (60 mL) and 53 glacial acetic acid (12 mL, 208 mmol) was added 54 tert-butyl 3-cyano-4-oxopiperidine-1-carboxylate (5.0 g, 22.3 mmol) at room temperature. The resulting mixture was stirred under reflux for 16 h. After removal of solvent under reduced pressure, the residue was dissolved in 38 EtOAc and washed with 2 N aqueous NaOH, brine, and dried over MgSO4. The solvent was removed under reduced pressure and the residue was purified by silica gel flash chromatography (5 to 55% EtOAc in hexanes) to give 55 tert-butyl 3-amino-2-(2-isobutoxy-6-methylphenyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate. MS: (ES) m/z calculated for C22H33N4O3 [M+H]+ 401.2, found 401.2., 914988-10-6
914988-10-6 tert-Butyl 3-cyano-4-oxopiperidine-1-carboxylate 42609283, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; CHEMOCENTRYX, INC.; FAN, Pingchen; LANGE, Christopher W.; MALATHONG, Viengkham; MALI, Venkat Reddy; PUNNA, Sreenivas; TANAKA, Hiroko; ZENG, Yibin; ZHANG, Penglie; (210 pag.)US2019/192491; (2019); A1;,
Piperidine – Wikipedia
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