89895-06-7, 1-(Piperidin-4-yl)ethanone hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,89895-06-7
0224] 1-(Piperidin-4-yl)ethanone hydrochloride(6.07 g, 21.85 mmol) obtained in Preparation Example 6-4 was dissolvedin acetonitrile (75 mL). Potassium carbonate (K2CO3) (5.83 g, 34.96 mmol) and iodoethane (CH3CH2I) (2.77 mL,28.41 mmol) were added dropwise to the resulting solution and the solution was stirred for 18 hrs. The solution wasevaporated under reduced pressure to concentrate, diluted with EtOAc, and washed with water. The washed organicsolvent was dried over anhydrous magnesium sulfate (MgSO4) to concentrate. The resulting residue was isolated andpurified by silica gel column chromatography (dimethylchloride/methanol = 10/1) to give the white title compound (5.18g, 76 %).1H NMR (400 MHz, CDCl3) delta 2.81 (m, 2H), 2.24 (s, 3H), 2.16 (m, 1H), 2.09 (m, 2H), 1.94 (m, 2H), 1.80 (m, 2H), 1.60(m, 2H), 1.48 (m, 3H).
89895-06-7 1-(Piperidin-4-yl)ethanone hydrochloride 44151897, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Beyondbio Inc.; MIN, Changhee; OH, Byungkyu; KIM, Yongeun; PARK, Changmin; (98 pag.)EP3255042; (2017); A2;,
Piperidine – Wikipedia
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