With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78190-11-1,1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid,as a common compound, the synthetic route is as follows.,78190-11-1
A mixture of piperidine-1,3-dicarboxylic acid 1-benzyl ester (3.0 g, 11.4 mmol), triethylamine (4.62 g, 45.6 mmol), and 1-propanphosphonic acid anhydride (3.63 g, 11.4 mol, 6.80 mL of a 50% w/w solution in ethyl acetate) and 2 aminoacetophenone hydrochloride (1.96 g, 11.4 mmol) in THF (55 mL) was stirred at rt for 16 h. The mixture was then concentrated, and the residue was dissolved in CH2Cl2. The solution was washed with 1 M NaOH, dried through cotton, and concentrated. Silica gel chromatography eluding with 1:2 hexanes/ethyl acetate gave the title compound as a pale yellow solid.
As the paragraph descriping shows that 78190-11-1 is playing an increasingly important role.
Reference：
Patent; Pfizer Inc; US2006/19975; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem