With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.769944-71-0,3-(4-Bromophenyl)piperidin-2-one,as a common compound, the synthetic route is as follows.
769944-71-0, Weighing the compound 4 (0.75 g, 2 . 96 mmol) dissolved in 15 mlTHF (tetrahydrofuran) after lowering the temperature to 0 C, adding borane tetrahydrofuran complex (6.65 ml, 1.0 M in THF, 6 . 65 mmol, CAS: 14044 – 65 – 6) stir at room temperature overnight, after adding several drops of dilute hydrochloric acid quenching reaction reflux 1.5 h, turns on lathe does solvent evaporation, adding an amount of the sodium hydroxide solution, dichloromethane is used for extraction (25 ml * 3), combined with the organic phase, washed with saturated sodium chloride (25 ml * 2), drying, filtering, concentrating add 25 ml water and 25 ml hydrochloric acid in 110 C reflow 3 h, the reaction is finished adding proper amount of sodium hydrate to ph 7, dichloromethane is used for extraction (30 ml * 3), combined with the organic phase, washed with saturated sodium chloride (30 ml * 2) concentrated under reduced pressure to obtain yellow solid that the target compound 5 (0.64 g, yield 90%).
As the paragraph descriping shows that 769944-71-0 is playing an increasingly important role.
Reference：
Patent; Southeast University; Cai Jin; Wang Yingying; Ji Min; Ning Yao; Wei Qing; Zhan Mengmeng; Liu Wenjing; (9 pag.)CN108409638; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem