768-66-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.
EXAMPLE 5 Synthesis of 2-chloro-2-(2,2,6,6-tetramethyl-1-piperidinylthio)imino acetonitrile A commercial 2.5M n-BuLi solution (71 mL, 177 mmol) is added dropwise to a solution of 2,2,6,6-tetramethylpiperidine (25 g, 177 mmol) in anhydrous tert-butyl methyl ether (100 mL) at -20 C. The above solution is transferred into an addition funnel and is added dropwise to a solution of 3,4-dichloro-1,2,5-thiadiazole (27.4 g, 177 mmol) in anhydrous tert-butyl methyl ether (270 mL) at -50 C. Water (200 mL) is added and the reaction is allowed to warm to rt. The organic layer is decanted and the aqueous layer is extracted with diethyl ether (250 mL). The combined organic layers are washed with a 10% aqueous solution of acetic acid (100 mL) and water (100 mL). Toluene is added and the solution is concentrated under vacuum to afford the title compound (34 g, 74%): 1H-NMR (CDCl3): delta (ppm) 1.32 (s, 12H); 1.54-1.64 (m, 6H); 13C-NMR (CDCl3): delta (ppm) 17.2, 27.5, 32.7, 41.0, 61.2, 100.0, 111.8; IR (cm-1): 2225 (CN).
As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.
Reference：
Patent; Borghese, Alfio; Mancuso, Vincenzo; Merschaert, Alain; US2009/156808; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem