With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7583-53-1,1-Methyl-3-piperidinemethanol,as a common compound, the synthetic route is as follows.
To a stirred solution of 1 -methyl-3 -hydroxymethylpiperidine (2 g, 15.5 mmol) in DCM (30 mL) at 0C, triethylamine (4.9 g, 46 mmol) and tosyl chloride (4.41 g, 23.2 mmol) were added and allowed the mixture to stir at room temperature for 6 h. After completion, the reaction mixture was diluted with water (30 mL) and extracted with DCM (3 x 30 mL). The combined organic layer was dried over sodium sulfate and concentrated. The resulting crude was purified by flash chromatography (silica gel, 12 g cartridge) using 0-20% EtOAc in hexanes as eluent to obtain (l-methylpiperidin-3-yl)methyl 4- methylbenzenesulfonate (Yield: 2.50 g, 58%) as white solid. LCMS (ES) m/z = 284.36 [M+H]+; NMR (400 MHz, DMSO-d6) d ppm: 0.87-0.95 (m, 1H), 1.33-1.50 (m, 4H), 1.63 (m, 1H), 1.80-1.85 (m, 2H), 2.06 (s, 3H), 2.42 (s, 3H), 2.46-2.52 (m, 1H), 3.90 (m, 2H), 7.48 (d, J= 8.0 Hz, 2H). 7.78 (d, J= 8.0 Hz, 2H).
As the paragraph descriping shows that 7583-53-1 is playing an increasingly important role.
Reference£º
Patent; JUBILANT BIOSYS LIMITED; VENKATESHAPPA, Chandregowda; D A, Jeyaraj; PENDYALA, Muralidhar; SIVANANDHAN, Dhanalakshmi; RAJAGOPAL, Sridharan; (233 pag.)WO2019/175897; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem