73874-95-0, tert-Butyl piperidin-4-ylcarbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
73874-95-0, 10 g (0.050 mol, 1 eq) of 4-boc-amino-piperidine, 6 g (0.060 mol, 1.2 eq) of tetrahydro- 4H-pyran-4-one, 16 g (0.075 mol, 1.5 eq) of sodium triacetoxyborohydride, and 3 g (0.050 mol, 1 eq) of acetic acid were combined in 600 mL of dichloroethane and stirred at ambient temperature. After two days, the reaction was washed with 2 x 200 mL saturated sodium bicarbonate. The organic layer was separated, dried with sodium sulfate, and evaporated to yield 9.2 g (65% yield) of 1 ,1-dimethylethyl [1-(tetrahydro-2H-pyran-4-yl)-4- piperidinyl]carbamate as a white solid. 1H-NMR (400 MHz, DMSO-Of6): delta 6.73 (d, J = 7.6 Hz, 1 H), 3.86 (m, 2H), 3.24 (app t, 2H), 3.16 (m, 1 H), 2.81 (m, 4H), 2.37 (m, 1 H), 2.07 (app t, 2H), 1.73-1.59 (m, 4H), 1.44-1.24 (m, 4H), 1.37 (s, 9H).
The synthetic route of 73874-95-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/36711; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem