61995-20-8,61995-20-8, Benzyl 3-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a suspension of trimethylsulfoxonium iodide (35.20 g, 0.16 mol) in t-BuOH (150 mL) was added t-BuOK (17.95 g, 0.16 mol) at 50C , the mixture turned to a cloudy suspension. The mixture was stirred at the same temperature for 1.5h. Compound 5-C (14.90 g, 64 mmol) was then added at that temperature and the mixture stirred at 50C for another 48h. The reaction mixture was cooled to room temperature and partitioned between saturated aqueous NH4CI and EtOAc. The organic phase was separated, dried (MgS04), filtered and concentrated under reduce pressure. The residue obtained was purified silica gel columnchromatography (EtOAc/Pet ether=1/6) to give (2.0 g, 1 1 %) as colorless oil. The structure was confirmed by LC-MS and H-NMR spectra. TLC: Rf=0.52 silica gel EtOAc/Pet ether=1/1 LC-MS : 262 ([M+1]+), H-NMR: 7.33 (m, 5H), 5.14 (s, 2H), 4.66 – 4.43 (m, 2H), 3.82 (d, J = 13.0 Hz, 1 H), 3.67 – 3.07 (m, 3H), 2.37 (m, 2H), 1.99 – 1.35 (m, 4H).
The synthetic route of 61995-20-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; YM BIOSCIENCES AUSTRALIA PTY LTD; BURNS, Christopher John; WO2014/32; (2014); A1;,
Piperidine – Wikipedia
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