With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52763-21-0,Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.
Preparation 29: Ethyl 1-benzyl-3-oxo-4-(prop-2-en-1-yl)piperidine-4-carboxylate (P29)A mixture of potassium ferf-butoxide (3.77 g, 33. 58 mmol) in THF (100 m L) was stirred at RT for 0.5 h. The resulting milky solution was cooled to 0 C, and then Ethyl l-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (5 g, 16.79 mmol) was added portion wise keeping the internal temperature below 5 C. The mixture was then warmed to RT and further stirred for 1 h, resulting in a yellow solution. After cooling to 0 C, allyl bromide (1.6 mL, 18.47 mmol) was added dropwise. The reaction mixture was warmed to RT and stirred overnight. The reaction solution was cooled to 0 C, and 50 m L of saturated N H4CI solution was added. After extraction and phase separation, the aqueous phase was extracted twice with 100 mL of EA. The combined organic phases were washed with 100 m L of saturated NaCI solution and dried; the solvent was evaporated under reduced pressure and the obtained crude material was purified by FC on silica gel (eluent: Cy to Cy/AcOEt 80/20) to give ethyl l-benzyl-3-oxo-4-(prop-2-en- l-yl)piperidine-4-carboxylate (p29, 4.23 g, y= 84%) as a yellow oil.MS (ES) (m/z): 302.23 [M+H]+., 52763-21-0
52763-21-0 Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride 2723880, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; SHIRE INTERNATIONAL GMBH; SEMERARO, Teresa; TARSI, Luca; MICHELI, Fabrizio; LUKER, Tim; CREMONESI, Susanna; (122 pag.)WO2016/42451; (2016); A1;,
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