With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.495414-64-7,1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
2-Bromo-1 -(4-fluoro-3-methyl-phenyl)-ethanone (2633.06 mg; 1 1.40 mmol; 1 .00 eq.) was added to a solution of 4-hydroxy-piperidine-1 ,4-dicarboxylic acid 1 -tert-butyl ester (2796.0 mg; 1 1 .40 mmol; 1 .00 eq.) and triethylamine (1 .92 ml; 13.67 mmol; 1 .20 eq.) in acetonitile (30 ml) at rt in one portion. The resulting mixture was stirred at RT for 100 min. The reaction mixture was diluted with 100 ml of ethyl acetate and washed with saturated NaHC03 once and brine twice. The organic layer was dried over MgS04 and then concentrated to yield the title compound as a light brown solid, which was used directly for the next step reaction. LC-MS (M+H = 396, obsd = 396), 495414-64-7
The synthetic route of 495414-64-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK PATENT GMBH; LAN, Ruoxi; CHEN, Xiaoling; XIAO, Yufang; HUCK, Bayard R.; GOUTOPOULOS, Andreas; WO2014/143612; (2014); A1;,
Piperidine – Wikipedia
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