Downstream synthetic route of 406233-26-9

406233-26-9, As the paragraph descriping shows that 406233-26-9 is playing an increasingly important role.

406233-26-9, 4-(4,4-Dimethylpiperidin-1-yl)benzoic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4.6 Acylsulfonamide (SZ5TA2)[ 0395] A solution of 15 (58 mg, 0.25 mmol), 22 (43 mg, 0.25 mmol), EDCI (60 mg, 0.314 mmol) and DMAP (8 mg, 0.065 mmol) in dichloromethane (10 mL) was stirred for 30 h. Product (SZ5TA2) (68 mg, 70percent) was isolated after flash chromatography (DCM: MeOH = 16: 1). Rf = 0.6 (DCM: MeOH = 8: 1). 1H-NMR (400 MHz, CDC13) delta: 8.70 (bs, 1H), 8.00 (d, J = 8 Hz, 2H), 7.63 (d, J= 8.4 Hz, 2H), 7.30 (d, J= 8 Hz, 2H), 6.82 (d, J= 7.6 Hz, 2H), 3.30 (t, J = 6 Hz, 4H), 2.40 (s, 3H), 1.46 (bs, 4H), 0.97 (s, 6H) ppm. 13C-NMR (100 MHz, DMSO- 6) delta: 165.1, 154.4, 144.5, 137.9, 130.9, 130.0, 128.3, 119.2, 113.4, 43.9, 38.0, 29.2, 28.3, 21.9 ppm. HRMS (ESI+) for [M+H]+; calculated: 387.1742, found: 387.1742 (error m/z = -1.8 ppm).

406233-26-9, As the paragraph descriping shows that 406233-26-9 is playing an increasingly important role.

Reference:
Patent; UNIVERSITY OF SOUTH FLORIDA; MANETSCH, Roman; KULKARNI, Sameer Shamrao; IYAMU, Iredia David; WANG, Hong-Gang; DOI, Kenichiro; GUIDA, Wayne C.; SANTIAGO, Daniel N.; DUBOULAY, Courtney J.; WO2012/21486; (2012); A2;,
Piperidine – Wikipedia
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