With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35856-62-3,Piperidine-1-sulfonyl chloride,as a common compound, the synthetic route is as follows.
To 0.350g (1. 62mmol) of 10001a in 1 OmL CH2CI2 was added 0.23 mL (1. 62mmol) of Et3N, then 0.446g (2. 42mmol) of 10004b in 5 mL CH2CI2 drop wise at rt. The reaction mixture was stirred at rt overnight. The reaction mixture was diluted with EtOAc, washed with a solution of aq. NH4CI and brine. The organic layers was dried over MgS04, filtered, concentrated in vacuo and purified by silica gel chromatography with 6 24% EtOAc in Hexane to yield 0.353g of product. Yield 60%.
35856-62-3, As the paragraph descriping shows that 35856-62-3 is playing an increasingly important role.
Reference：
Patent; SCHERING CORPORATION; WO2005/87721; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem