Downstream synthetic route of 3515-49-9

3515-49-9, As the paragraph descriping shows that 3515-49-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3515-49-9,3-(Piperidin-4-ylmethyl)-1H-indole,as a common compound, the synthetic route is as follows.

EXAMPLE 6 3-Chloro-4-[(4-piperidyl)-methyl]-quinoline The operation is as in Example 1, but starting from 13.4 g of 4-(3-indolyl-methyl)-piperidine and 0.54 g of triethylbenzylammonium chloride in 130 ml of chloroform and 19.5 g of sodium hydroxide in solution in 39 ml of water. 4.2 g of 3-chloro-4-[(4-piperidyl)-methyl]-quinoline are finally obtained in the form of the dihydrochloride melting above 260 C.

3515-49-9, As the paragraph descriping shows that 3515-49-9 is playing an increasingly important role.

Reference£º
Patent; Pharmindustrie; US4405789; (1983); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem