With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3202-33-3,4-Phenoxypiperidine,as a common compound, the synthetic route is as follows.
To a solution of 4-phenoxypiperidine (500 mg, 2.82 mmol) in DMF (6 mL) was added K2CO3 (0.78 g, 5.64 mmol) and 2-bromoethanol (0.39 g, 3.1 mmol). The reaction mixture was heated to 50C and stirred at that temperature for 3 h. TLC showed most of the product. The reaction was poured into water and extracted with DCM (3 x 40 mL). The combined organics were washed with saturated aqueous NaCl (2 x 20 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The resulting oil was purified by flash column chromatography with a gradient elution of DCM (95%) and MeOH (5%) to DCM (85%) and MeOH (15%) to provide 2-(4- phenoxypiperidin-1-yl)ethanol (260 mg, 1.17 mmol) as a yellow solid.
3202-33-3, 3202-33-3 4-Phenoxypiperidine 18878, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; SUNOVION PHARMACEUTICALS INC.; HEFFERNAN, Michele L.R.; HARDY, Larry Wendell; BROWN, Scott P.; HERMAN, Lee W.; (180 pag.)WO2018/26371; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem