With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.236406-39-6,8-Boc-2,8-Diazaspiro[4.5]decane,as a common compound, the synthetic route is as follows.
At room temperature,To a solution of tert-butyl 2,8-azaspiro[4,5]decane-8-carboxylate (192 mg, 0.88 mmol) in EtOAc (15 mL)And potassium carbonate (276 mg, 2 mmol),Stir at room temperature for 2 hours.Distilled water (30 mL) was added to the reaction mixture, and ethyl acetate (20 mL¡Á3).The layers were combined, dried over anhydrous magnesium sulfate, and concentrated, then purified by silica gel column (DCM: MeOH_NH3H2O=200:10:0.2)A pale yellow oil (260 mg).
The synthetic route of 236406-39-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zhejiang Sitaili Pharmaceutical Co., Ltd.; Chinese Academy Of Medical Sciences Pharmaceutical Bio-technology Institute; Liu Mingliang; Guo Huiyuan; Lv Kai; Wang Apeng; Chai Yun; Huang Guocheng; Tao Zeyu; Li Xiaoning; Chen Shihong; (23 pag.)CN108484601; (2018); A;,
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