19365-08-3, 3-Hydroxypiperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 3-hydroxypiperidin-2-one (3.0 g, 26.1 mmol) and 1H-imidazole (1.95 g, 28.7 mmol) in DMF (30 mL) was slowly added TBSCl (5.11 g, 33.9 mmol) at RT. The reaction mixture was degassed with nitrogen 3 times and stirred at RT for 16 hours. The resulting mixture was poured into ice-water (100 mL) and extracted with EA (3 x 50 mL). The combined organic layers were washed with brine (3 x 30 mL), dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated under vacuum. The residue was purified by a silica gel column chromatography, eluting with 50% of EA in PE to afford the title compound: LCMS [M + 1]+: 230.
19365-08-3, The synthetic route of 19365-08-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DONG, Shuzhi; SCOTT, Jack, D.; TANG, Haiqun; ZHAO, Zhiqiang; YANG, Dexi; GU, Xin; JIANG, Jinlong; XIAO, Li; (209 pag.)WO2019/18186; (2019); A1;,
Piperidine – Wikipedia
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