19365-07-2, 5-Hydroxypiperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
PREPARATION S 2-Piperidon-5-yl p-Toluenesulfonate 2-Piperidon-5-ol (0.575 g, 5 mmoles) was dissolved in 15 ml. dimethylformamide and the solution was diluted with 50 ml. dichloromethane. The solution was cooled to 0 C. under nitrogen and 0.95 g. (5 mmoles) p-toluenesulfonyl chloride and 1.22 g. (10 mmoles) 4-dimethylaminopyridine was added. The solution was stirred at 0 C. for 3 hrs., then at 25 C. for 20 hrs. The reaction mixture was then diluted with 125 ml. dichloromethane and the solution was washed with 20 ml. 1N aqueous hydrochloric acid solution, two 20 ml. portions of water and 20 ml. saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. Diethyl ether was added to the residue and the title compound was obtained as the resulting solid product following filtration (0.8 g, 60% yield). The NMR spectrum of the title compound as a deuterochloroform solution had peaks at 2.4 (s) and 1.67-2.6 (c) (total 7H); 3.43 (c, 2H); 4.86 (m, 1H); 6.96 (b, 1H); 7.3 (d, 2H); and 7.76 (d, 2H)ppm.
19365-07-2, The synthetic route of 19365-07-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Pfizer Inc.; US4772597; (1988); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem