189333-49-1, 3-Benzyl-3,9-diazaspiro[5.5]undecane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
b. Preparation of final compound 5; A mixture of intermediate compound 3 (prepared according to Al.c) (0.033 mol), 3- (phenylmethyl)-3,9-diazaspiro-[5.5]-undecane (0.033 mol), Ti (iPrO)4 mol) and Pd/C (1.5 g) in thiophene (1 ml) and methanol (150 ml) was hydrogenated at 50C for 18 hours under a 5 bar pressure, then filtered over celite. Celite was washed with CH30H. The filtrate was evaporated till dryness. The residue was dissolved in CH2C12. K2C03 10 % was added. The mixture was stirred at room temperature for 30 minutes, then filtered over celite. Celite was washed with CH2C12. The filtrate was extracted with CH2C12. The organic layer was separated, dried (MgS04), filtered, and the solvent was evaporated. The residue (20 g) was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH/NH4OH 94/6/0.5; 20-45 mum). Two fractions were collected and the solvent was evaporated. The residue was dissolved in iPrOH and converted into the hydrochloric acid salt. The precipitate was filtered off and dried. Yield: 3.5 g of final compound 5 (14 %) (melting point: 183C).
189333-49-1, The synthetic route of 189333-49-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/97795; (2005); A1;,
Piperidine – Wikipedia
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