1892-22-4, 3-Aminopiperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A suspension of 4 ‘- [(25) -2- {[(GammaalphaMu5-4- {[(betaGamma-BetaupsilonIotaomicron gammaomicron ^ omicronetagamma1) alphaetaiotaetaomicron] etaiotaepsilon11iotagamma1} omicrongammaomicron1omicron1iotaepsilon gamma1) – carbonyl] amino} -3- (l / i- indazol-6-ylamino) -3-oxopropyl] -2-methylbiphenyl-4-carboxylic acid (100 mg, 0.153 mmol) in ethyl acetate (2.5 ml) was treated with 3-aminopiperidine-2-one (19.2 mg, 0:17 mmol) and N , N-diisopropylethylamine (0.08 mL, 0:46 mmol).The suspension was treated with a 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide solution (50% in DMF, 0.27 mL, 0.46 mmol) and then 3 at reflux (oil bath temperature 80 C) stirred.The reaction mixture was added with DMF (1 ml) and the ethyl acetate was removed on a rotary evaporator.The residue was mixed with a little water and acetonitrile, filtered through a Millipore filter and purified by preparative HPLC (eluent: gradient of acetonitrile / water with 0.1% trifluoroacetic acid).This gave 49.1 mg (42% d. Th.) Of the title compound., 1892-22-4
1892-22-4 3-Aminopiperidin-2-one 5200225, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROEHN, ULRIKE; ELLERMANN, MANUEL; STRASSBURGER, JULIA; WENDT, ASTRID; ROEHRIG, SUSANNE; WEBSTER, ROBERT ALAN; SCHMIDT, MARTINA VICTORIA; TERSTEEGEN, ADRIAN; BEYER, KRISTIN; SCHAEFER, MARTINA; BUCHMUELLER, ANJA; GERDES, CHRISTOPH; SPERZEL, MICHAEL; SANDMANN, STEFFEN; HEITMEIER, STEFAN; HILLISCH, ALEXANDER; ACKERSTAFF, JENS; TERJUNG, CARSTEN; (489 pag.)TW2016/5810; (2016); A;,
Piperidine – Wikipedia
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