187834-88-4, 1-Boc-isonipecoticacidhydrazide is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
187834-88-4, To a solution of (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Intermediate 10, 200 mg, 0.581 mmol) in DMF (3.8 mL) were added tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate (212 mg, 0.871 mmol), DIPEA (0.304 mL, 1.74 mmol), HATU (331 mg, 0.871 mmol) at room temperature, The reaction mixture was stirred at room temperature for 18 hours and diluted with EtOAc. The mixture was washed with saturated aq. NH4Cl and brine, dried over Na2SO4, filtered and concentrate in vacuo. The residue was purified by column chromatography on SiO2 (EtOAc only to DCM_MeOH=20:1 to 10:1) to give the (R)-tert-butyl 4-(2-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonyl)hydrazinecarbonyl)piperidine-1-carboxylate (265 mg, 80%) as a white solid. MS: 569.90 [MH+].
The synthetic route of 187834-88-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HANDOK INC.; CMG Pharmaceutical Co., Ltd.; Kim, Moonsoo; Lee, Chaewoon; Lee, Gilnam; Yoon, Cheolhwan; Seo, Jeongbeob; Kim, Jay Hak; Lee, Minwoo; Jeong, Hankyul; Choi, Hyang; Jung, Myung Eun; Lee, Ki Nam; Kim, Hyun Jung; Kim, Hye Kyoung; Lee, Jae Il; Lee, MinWoo; Kim, Misoon; Choi, Soongyu; (124 pag.)US2016/168156; (2016); A1;,
Piperidine – Wikipedia
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