Safety of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, is researched, Molecular C24H9F18P, CAS is 175136-62-6, about Chemoselective Reduction of Phosphine Oxides by 1,3-Diphenyl-Disiloxane.
Reduction of phosphine oxides to the corresponding phosphines represents the most straightforward method to prepare these valuable reagents. However, existing methods to reduce phosphine oxides suffer from inadequate chemoselectivity due to the strength of the P:O bond and/or poor atom economy. Herein, the authors report the discovery of the most powerful chemoselective reductant for this transformation to date, 1,3-diphenyl-disiloxane (DPDS). Additive-free DPDS selectively reduces both secondary and tertiary phosphine oxides with retention of configuration even in the presence of aldehyde, nitro, ester, α,β-unsaturated carbonyls, azocarboxylates, and cyano functional groups. Arrhenius anal. indicates that the activation barrier for reduction by DPDS is significantly lower than any previously calculated silane reduction system. Inclusion of a catalytic Bronsted acid further reduced the activation barrier and led to the 1st silane-mediated reduction of acyclic phosphine oxides at room temperature
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem