With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154775-43-6,3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid,as a common compound, the synthetic route is as follows.,154775-43-6
(a) Di-t-butyl [[4-[[N-[3-(1-t-butyloxycarbonylpiperidin-4-yl)propionyl]-N-methylamino]acetyl]-o-phenylene]dioxy]diacetate 3-(1-t-butyloxycarbonylpiperidin-4-yl)propionic acid (257 mg), di-t-butyl [[4-[(N-methylamino)acetyl]-o-phenylene]dioxy]diacetate hydrochloride (446 mg), N-methylmorpholine (101 mg), benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP reagent, 442 mg), and a catalytic amount of 4-dimethylaminopyridine were dissolved in 5 ml of dimethylformamide, and the mixture was stirred at room temperature for 3 hours. After ethyl acetate (100 ml) was added to the reaction mixture, the resulting mixture was washed with water. The solvents were removed under reduced pressure. The residual mixture was purified by column chromatography on silica gel to give 285 mg of the title compound from the fraction eluted with n-hexan:ethyl acetate=3:1. 1 H-NMR (CDCl3) delta: 1.04-1.15 (m, 2H), 1.38-1.54 (m, 28H), 1.54-1.75 (m, 4H), 2.35-2.48 (m, 2H), 2.58-2.75 (m, 2H), 3.08 (s, 3H), 3.98-4.29 (m, 2H), 4.62 (s, 2H), 4.66 (s, 2H), 4.77 (s, 2H), 6.82 (d, J=8 Hz, 1H), 7.47 (s, 1H), 7.60 (d, J=8 Hz, 1H). SIMS (m/z): 649 (M+ +1).
The synthetic route of 154775-43-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Meiji Seika Kabushiki Kaisha; US5594004; (1997); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem